Acellular Skin Substitutes Market - Forecast(2024 - 2030)

Acellular Skin Substitutes Market size is estimated to reach $654.3 million by 2027, growing at a CAGR of 8.2% during the forecast period 2022-2027. Acellular skin substitutes are collagen-abundant matrices made by eliminating the cellular constituents (protein and collagen matrix) of human cadaver skin. The establishment of bioengineered skin was driven by the crucial requirement to wrap wide-ranging burn wounds in patients with inadequate skin for grafting. Bioengineered skin substitutes have also been extensively utilized for an assortment of incessant wounds with the objective of quicker healing, decreased contamination, and superior cosmetic appearance. Relying on the source, skin substitutes can be biological or synthetic. Synthetic substitutes may be prepared from synthetic materials. Certain synthetic substitutes also include biological material and may be mentioned as biosynthetic skin substitutes. In 1981, O’Conner and his group utilized cultured autologous epithelium to wrap burn defects for the earliest time. In numerous kinds of wound coverage, there is a requirement to utilize cultured autologous keratinocytes for permanent skin coverage. There are three chief kinds of commercially available engineered skin substitutes inclusive of epidermal, dermal, and dermoepidermal. Each of them could be constituted of scaffold, appropriate cell types or growth determinants. These substitutes could possess autologous, allogeneic, or xenogeneic origin. Furthermore, they may be cellular or acellular. They are utilized to expedite injury healing and restore normal skin functions with pain alleviation.

The rising pervasiveness of incessant skin ailments requiring the application of different kinds of skin substitutes like bioengineered skin substitutes across the world is set to drive the Acellular Skin Substitutes Market. The smooth accessibility of advanced treatment facilities, skilled physicians and specialists and the modest cost of treatment in countries like India, Thailand, Malaysia, and Singapore impelling the medical tourism sector is set to propel the growth of the Acellular Skin Substitutes Market during the forecast period 2022-2027. This represents the Acellular Skin Substitutes Industry Outlook.

Report Coverage

The report: “Acellular Skin Substitutes Market Forecast (2022-2027)”, by Industry ARC, covers an in-depth analysis of the following segments of the Acellular Skin Substitutes Market.

By Source Of Cells: Animal, Human.
By Application: Diabetic Foot Ulcers, Lower Extremity Venous Ulcers, Ulcers Of Mixed Etiology, Pressure Ulcers, Plastic Surgeries.
By Geography: North America (U.S, Canada and Mexico), Europe (Germany, France, UK, Italy, Spain, Russia and Rest of Europe), Asia-Pacific (China, Japan, South Korea, India, Australia & New Zealand, and Rest of Asia-Pacific), South America (Brazil, Argentina, Chile, Colombia, Rest of South America), and Rest Of The World (Middle East, Africa).

Key Takeaways

• Geographically, North America Acellular Skin Substitutes Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027 owing to the increasing predominance of vascular ailments and the surge in demand for skin substitutes like bioengineered skin substitutes in the North American region.
• Acellular Skin Substitutes Market growth is being driven by the emerging inclination for acellular skin substitutes which may be bioengineered skin substitutes for implant-based skin surgery. However, presently accessible skin surgeries are mostly invasive and need prolonged healing time and treatment cost and these are some of the major factors hampering the growth of Acellular Skin Substitutes Market. 
• Acellular Skin Substitutes Market Detailed Analysis on the Strength, Weakness, and Opportunities of the prominent players operating in the market will be provided in the Acellular Skin Substitutes Market report. 

Acellular Skin Substitutes Market Segment Analysis – By Source Of Cells:

The Acellular Skin Substitutes Market based on source of cells can be further segmented into Animal and Human. The Human Segment held the largest market share in 2021. This growth is owing to the surging application of Allografts which are products extracted from the human cadaver skin. Products extracted from human cells are inclusive of AlloDerm and GraftJacket. The heightened security and compatibility of acellular skin substitutes extracted from human cells are further propelling the growth of the Human segment.

Furthermore, the Animal segment is estimated to grow with the fastest CAGR of 9.3% during the forecast period 2022-2027 owing to the extensive application of products extracted from animal sources established by cultivating living tissue from different donor animals like bovine, equine, and porcine apart from the utilization of bioengineered skin substitutes.

Acellular Skin Substitutes Market Segment Analysis – By Application:

The Acellular Skin Substitutes Market based on application can be further segmented into Diabetic Foot Ulcers, Lower Extremity Venous Ulcers, Ulcers Of Mixed Etiology, Pressure Ulcers and Plastic Surgeries. The Diabetic Foot Ulcers Segment held the largest market share in 2021. This growth is owing to the surging application of acellular skin substitutes for treatment of Diabetic Foot Ulcers. The most excellent healing rates at 12 weeks have been achieved with dermal cellular substitutes (Epifix®, 100% and Amnioband®, 85%) and with dermal acellular substitutes (Allopatch®, 80% and Hyalograft®, 78.8%). The extensive application of acellular dermal matrices as convenient dressings in skin wounds, inclusive of hard healing or non-healing wounds apart from likely utilization of bioengineered skin substitutes is further propelling the growth of this segment.

Furthermore, the Lower Extremity Venous Ulcers segment is estimated to grow with the fastest CAGR of 9.5% during the forecast period 2022-2027 owing to the extensive application of acellular dermal regenerative tissue matrix in the healing of lower extremity injuries involving venous ulcers apart from the application of bioengineered skin substitutes.

Acellular Skin Substitutes Market Segment Analysis – By Geography:

The Acellular Skin Substitutes Market based on geography can be further segmented into North America, Europe, Asia-Pacific, South America, and Rest of the World. North America (Acellular Skin Substitutes Market) held the largest share with 35% of the overall market in 2021. The growth of this region is owing to the increasing count of wounds requiring the application of bioengineered skin substitutes and the surging awareness among people in the North American region. The expanding geriatric population is further propelling the growth of the Acellular Skin Substitutes Market in the North American region.

Furthermore, the Asia-Pacific region is estimated to be the region with the fastest CAGR rate over the forecast period 2022-2027. This growth is owing to factors like increasing demand for acellular skin substitutes including bioengineered skin substitutes in the Asia-Pacific region. The heightening geriatric population in countries like South Korea and Japan is further fuelling the progress of the Acellular Skin Substitutes Market in the Asia-Pacific region.

Acellular Skin Substitutes Market - Drivers

Surging Applications Of Bioengineered Skin Substitutes Are Projected To Drive The Growth Of Acellular Skin Substitutes Market:

Bioengineered skin includes an external epidermal layer and/or a dermal layer (the layer of skin between the epidermis and the subcutaneous tissue) entrenched into an acellular matrix (a backing structure) producing a biological skin substitute. This ‘artificial’ tissue can be developed from the patient's own cells or from another ‘allogeneic‘(non-self) source. Nearly all commercial bioengineered skin includes sheets of cells extracted from neonatal (allogenic) foreskin. Commercial bioengineered skin products are accessible in the U.S. like Alloderm® [LifeCell Inc. Woodlands, Texas, USA]. It includes skin tissue contributed from cadavers to prepare an acellular dermal matrix that has been freeze-dried subsequent to processing. It is utilized to act as a scaffold for normal tissue remodeling. The collagen framework offers tenacity to the skin and includes no cells that can bring about denial or irritation. The period of contact is permanent. It is accessible in Australia on a case-by-case basis. The U.S. FDA-authorized indications include burns and full-thickness wounds. Bioengineered skin substitutes include acellular dermal substitutes or derma regeneration templates (DRT) that are porous 3D biomaterials (non-containing cells) utilized in the missing dermis subsequent to wound debridement. The product OASIS® comes with the composition: Porcine acellular lyophilized small intestine submucosa–non crosslinked. OASIS® Wound Matrix was exposed to a randomized controlled investigation in 120 patients with chronic venous leg ulcers. Considerably greater wounds (55% vs. 34%) were noticed to be recovered when compared with traditional therapy. The surging applications of Bioengineered Skin Substitutes are therefore fuelling the growth of the Acellular Skin Substitutes Market during the forecast period 2022-2027.

Proliferating Innovative Efforts Are Expected To Boost The Demand Of Acellular Skin Substitutes:

Bioengineered skin grafts or substitutes (also termed tissue-engineered skin substitutes, artificial skin, living skin equivalents, human skin equivalents, or skin alternatives) are utilized when the patient possesses a restricted quantity of skin to utilize for grafts or are too sick to bear the building of further wound sites. Overcurrent decades, scientists and surgeons have collaborated to establish different bioengineered and synthetic products as a substitute for skin grafts. Decellularized dermis appears to persist as the most excellent alternative with no additional acellular scaffold being clinically proven to acquire superior outcomes yet. Typically, chemically cross-linked products were observed to be less efficient in skin tissue engineering. Biocompatibility could be improved by preseeding substitutes with fibroblasts to permit certain organic scaffold remodeling prior to product use. Skin substitutes are a convenient tool in plastic and reconstructive surgery practices as a substitute for skin grafts. In the selection of alternatives, the general plastic surgery principle of taking the place of like tissue with like tissue seems to still hold good, and products most mirroring the organic dermal extracellular matrix need to be favored. Acellular dermal allografts spring from deepithelialized cadaveric skin. Dermacell AWM is a technologically progressive human acellular dermal matrix that is decellularized utilizing Matracell®, a proprietary, patented, and validated processing technology. Matracell eliminates at least 97% of donor DNA, permitting accelerated cellular infiltration and re-vascularization. Dermacell AWM is terminally sterilized, ready to apply without refrigeration or re-hydration. The proliferating innovative efforts are therefore driving the growth of the Acellular Skin Substitutes Market during the forecast period 2022-2027.

Acellular Skin Substitutes Market – Challenges

Disadvantages Of Skin Substitutes Are Hampering The Growth Of The Acellular Skin Substitutes Market:

The soaring cost makes skin substitutes unaffordable for numerous people. On the website for MDsave, the cost of a Skin Substitute Graft or Harvesting in Florida extends from $2,711 to $3,453. Biological skin grafts may be economical in comparison with synthetic grafts. There may be a dearth of plastic surgeons who are knowledgeable in utilizing them. Since certain tissues or cells in skin substitutes may spring from cows, pigs or infants, these may not be culturally agreeable to all individuals. Therefore, it is essential to brief the recipient of the contents of the skin substitute prior to it being utilized. Tissues from additional species can lead to a reaction in allergic individuals. These issues are thus hampering the growth of the Acellular Skin Substitutes Market.

Acellular Skin Substitutes Industry Outlook:

Novel product launches, mergers & acquisitions, expansions, joint ventures, collaborations, and heavy investment in research and development are key strategies adopted by players in the Acellular Skin Substitutes Market. Key companies of this market are:

1. Acelity L.P., Inc.
2. Integra LifeSciences Corporation
3. Smith & Nephew plc.
4. Amarantus BioScience Holdings
5. Organogenesis, Inc.
6. Molnlycke Health Care
7. Medtronic
8. Tissue Regenix Ltd.
9. Stratatech – Mallinckrodt Pharmaceuticals
10. ConVatec

Recent Developments

• In November 2021, Smith+Nephew, announced the introduction of CORI - handheld robotics, a progressive system for both complete and partial knee arthroplasties. The CORI system is a condensed and completely mobile solution including a 3-D intra-operative imaging system with a progressive robotic sculpting tool. The robotic system permits surgeons to assess, plan, and carry out a knee surgery that is customized to the patient’s exclusive anatomy in theatre.
• In January 2021, Integra LifeSciences Holdings Corporation announced that it finished the formerly-revealed gain of ACell, Inc. “Acquiring ACell and its proprietary MatriStem UBM™ technologies will enable Integra to provide more comprehensive complex wound management solutions to address our customers’ most pressing clinical challenges,” pronounced Peter Arduini, President, and CEO, Integra LifeSciences. Sullivan & Cromwell LLP is serving as a legal advisor to Integra.
• In February 2020, Integra LifeSciences Holding Corporation launched AmnioExcel® Plus Placental Allograft Membrane, its most recent wound care offering to back soft tissue repair. AmnioExcel Plus is a next-generation, thicker, tri-layer, non-side particular allograft including amnion-chorion-amnion layers that help in building an ambiance to support the closure of complicated injuries. The proprietary DryFlex® processing technology conserves the basic development determinants, cytokines, and extracellular matrix (ECM) discovered in native placental tissue.

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