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Humanized Mouse Model Market - Forecast(2024 - 2030)
Humanized Mouse Model Market Overview
Humanized Mouse Model Market size was valued at $83.29 million in 2020, and is anticipated to reach $86.98 million by the end of 2026 growing at a CAGR of 8.2% during the forecast period 2021-2026. The humanized mouse model industry growth rate is attributed to the growing incidences of chronic disorders and increasing demand for effective therapeutic drugs and is anticipated bringing new opportunities. Basic science, safety evaluation for large molecule therapeutics, simulation of some human-specific infectious diseases, and efficacy testing of immunotherapy approaches all use humanised mouse models. In both cells and tissues, the human protein is expressed, while the mouse protein is silenced. Humanized mouse models are used to study cancer genetics, Auto immune diseases, regenerative medicine, human hematopoiesis, infectious diseases, transplantation, and autoimmunity. They improve the translational value of preclinical research by allowing researchers to gain a better understanding of disease pathways. Apart from this, the model requires accurate risk assessment and thorough analysis to preserve the physiological expression and regulation of the human gene inserted into the mouse genome. The genes and proteins of both the mouse and the human are examined for accuracy and structure in order to determine the optimum expression and functionality of the human protein in a mouse environment. Nonetheless, speedy technological advancements have been seen in the area, leading to the development of transgenic mouse, knock-in mouse, and knock-out mouse.
Report Coverage
The report: “Humanized Mouse Model Market Forecast (2021-2026)”, by Industry ARC, covers an in-depth analysis of the following segments of the Humanized Mouse Model Market:
By Type: Cell-based Humanized Mouse Model and Genetic Humanized Mouse Model.
By Applications: Immunology & Infectious Diseases, Neuroscience, Oncology, Hematopoiesis, Toxicology and Others.
By End-Users: Contract Research Organizations (CROs), Pharmaceutical & Biotechnology Companies and Academic & Research Institutes.
By Geography: North America (U.S, Canada, Mexico), Europe (Germany, UK, France, Italy, Spain, Russia and Others), APAC (China, Japan, India, South Korea, Australia and Others), South America(Brazil, Argentina and Others) and RoW (Middle East and Africa).
Key Takeaways
- North America dominated the Humanized Mouse Model market with a share of 35.60% in the year 2020.
- The factors such as growing aging population and rising number of diagnostic imaging are amongst the major factor projected to impel growth of Humanized Mouse Model market.
- Additionally, factors such as development of automated diagnostic imaging systems for laboratories and hospitals to provide efficient, accurate, and error-free diagnosis and increasing government investments are to create opportunities paving a way for the growth in the market during forecast period 2021-2026.
Global Humanized Mouse Model Market, By Type 2020(%)
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Humanized Mouse Model Market Segment Analysis - By Application
In 2020, on the basis of application, oncology segment accounted for the largest segmental revenue of the humanized mouse model market. The oncology segment held the largest market on account of the rising number of cancer research activities. This segment is projected to witness healthy growth throughout the forecast period 2021-2026 with a CAGR of 8.80%. This is owing to its vast range of applications in a variety of oncological fields coupled with advanced healthcare facilities and growing healthcare expenditure. Furthermore, there is an increasing innovation to develop humanized mouse models tailored to meet the specific needs of cancer research. All these factors are anticipated to fuel market growth during the forecast period 2021-2026.
Humanized Mouse Model Market Segment Analysis - By End Users
On the basis of end users, contract research organizations (CROs) segment accounted for the largest segmental revenue of the humanized mouse model market in 2020. The largest share can be attributed to the rise in the number of pharmaceutical companies outsourcing their preclinical studies to CROs. In addition, contract research organisations (CROs) are focusing on using these models to produce new drugs in order to gain a profitable market share. They are also interested in drug toxicity assessment and preclinical analysis. Furthermore, biotechnology corporations fund basic and advanced medical and veterinary research programs.
On the other hand, academic & research institutes segment is projected to dominate over the forecast period 2021-2026 with a CAGR of 8.50%. Owing to the rising demand for mice models in academic institutions, academic and research institutes are expected to expand at a healthy rate. For pharmacology education, academic institutions use preserved mice models to understand drug toxicity behavior. In addition, these models are being used in academia to educate and prepare a new generation of scientists and facility managers. Yale University, for example, created a novel HIV drug that suppressed the HIV virus in humanised mice and was found to be less toxic. The University of Pittsburgh and Temple University conducted a related study to exclude HIV DNA from the genomes of humanised mice. Both of these factors would contribute to the growth of the segmental market.
Humanized Mouse Model Market Segment Analysis - By Geography
North America is the major region dominating the Humanized Mouse Model market with a market share of 35.60% in the year 2020. This can be attributed to the growth in this regional segment and can primarily be attributed to growing biomedical research, preclinical activities by CROs and pharmaceutical R&D, continued and responsible use of animals ensured by animal care organizations, increasing monoclonal antibody production in the US along with growing stem cell research, and government support for the development of protein drugs in Canada have fueled the regional market. Moreover, increasing number of research and development activities with increasing need for early-stage diagnose of various types of cancer & cardiovascular diseases are also driving regional market growth.
However, Asia-Pacific is projected to be the significant-growing market growth CAGR during the forecast period 2021-2026. This is owing to foreign R&D partnerships in China, which include measures to shorten drug approval times and mandate animal testing for both prescription drugs and cosmetics, resulting in increased government and private sector investment in China's life sciences sector. Apart from these, the creation of bio-clusters to boost India's biotechnology, growth in translational and biomedical research in Singapore, increase in animal research in Malaysia, and ongoing biomedical research activities in Australia are all expected to drive the market in the area.
Humanized Mouse Model Market Drivers
Rising Demand For Personalized Medicine
The humanized mouse model market is poised to receive upswing owing to the rising demand for personalized medicine as these medicines are designed through the use of animal models, particularly mice models. Human tissues are transplanted into immune-deficient models, and the disease expression is registered. Following that, the model is treated with a variety of drugs or gene therapies in order to find the most appropriate therapy, resulting in appropriate or customized medication for patients and thereby augmenting factors that will impact the global market. Furthermore, advancements in genomics, proteomics, and metabolomics; the completion of the Human Genome Project; the growth of tailored diagnostics and therapeutics; and the increasing focus on wellbeing, wellness, and prevention are all driving demand for personalised medicine.
Humanized Mouse Model Market Challenges
High Cost Of Humanized Models
Despite several drivers, one of the major factor hindering is the high cost of humanized models which is restraining the its usage in experiments as humanized models used in experiments can cost thousands of dollars even in the case of a single patient. Moreover, using humanized models in government-funded basic research can also be cost-prohibitive thereby, challenging the regional market growth.
Humanized Mouse Model Market Landscape
Product launches, mergers and acquisitions, joint ventures and geographical expansions are key strategies adopted by players in the Humanized Mouse Model Market. In 2020, Humanized mouse model market share is fragmented by the top ten players present in the market. The humanized mouse model market top 10 companies are The Jackson Laboratory, Taconic Biosciences, Inc., Harbour BioMed, HuMurine Technologies, Inc., Vitalstar Biotechnology Co. Ltd., Crown Bioscience, Inc., ingenious targeting laboratory, Axenis S.A.S., TRANS GENIC, Inc., genOway S. A. and others.
Acquisitions/Product Launches
- In April 2019, Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces the launch of TruBIOME®, a first of its kind solution enabling the generation and maintenance of mice with custom microbiome profiles.
Relevant Reports:
Report Code: HCR 0083
Report Code: HCR 28806
For more Lifesciences and Healthcare related reports, please click here
1. Humanized Mouse Model Market - Overview
1.1 Definitions and Scope
2. Humanized Mouse Model Market - Executive Summary
2.1 Market Revenue and Key Trends by Company
2.2 Key trends by Type
2.3 Key trends by End Users
2.4 Key trends by Geography
3. Humanized Mouse Model Market – Comparative Analysis
3.1 Product Benchmarking – Key Companies
3.2 Financial Analysis – Key Companies
3.3 Market Value Split by Key Companie
3.4 Patent Analysis – Key Companies
3.5 Pricing Analysis
4. Humanized Mouse Model Market - Startup Companies Scenario Premium
4.1 Key Startup Company Analysis by
4.1.1 Investment
4.1.2 Revenue
4.1.3 Venture Capital and Funding Scenario
5. Humanized Mouse Model Market – Industry Market Entry Scenario Premium Premium
5.1 Regulatory Framework Overview
5.2 New Business and Ease of Doing business index
5.3 Case Studies of Successful Ventures
6. Humanized Mouse Model Market Forces
6.1 Market Drivers
6.2 Market Constraints/Challenges
6.3 Porters five force model
6.3.1 Bargaining power of suppliers
6.3.2 Bargaining powers of customers
6.3.3 Threat of new entrants
6.3.4 Rivalry among existing players
6.3.5 Threat of substitutes
7. Humanized Mouse Model Market – Strategic Analysis
7.1 Value Chain Analysis
7.2 Opportunities Analysis
7.3 Market Life Cycle
8. Humanized Mouse Model Market - By Type (Market Size –$Million/$Billion)
8.1 Cell-based Humanized Mouse Model
8.1.1 CD34
8.1.2 PBMC
8.1.3 BLT
8.2 Genetic Humanized Mouse Model
9. Humanized Mouse Model Market - By Application (Market Size –$Million/$Billion)
9.1 Immunology & Infectious Diseases
9.2 Neuroscience
9.3 Oncology
9.4 Hematopoiesis
9.5 Toxicology
9.6 Others
10. Humanized Mouse Model Market - By End-Users (Market Size –$Million/$Billion)
10.1 Contract Research Organizations (CROs)
10.2 Pharmaceutical & Biotechnology Companies
10.3 Academic & Research Institutes
11. Humanized Mouse Model Market - By Geography(Market Size –$Million/$Billion)
11.1 North America
11.1.1 U.S.
11.1.2 Mexico
11.1.3 Canada
11.2 Europe
11.2.1 U.K.
11.2.2 France
11.2.3 Germany
11.2.4 Russia
11.2.5 Italy
11.2.6 Spain
11.2.7 Rest of Europe
11.3 Asia Pacific
11.3.1 China
11.3.2 India
11.3.3 Japan
11.3.4 South Korea
11.3.5 Australia & New Zealand
11.3.6 Rest of APAC
11.4 South America
11.4.1 Brazil
11.4.2 Argentina
11.4.3 Others
11.5 Rest of the World
11.5.1 Middle East
11.5.2 Africa
11.5.3 South America
12. Humanized Mouse Model Market - Entropy
13. Humanized Mouse Model Market – Industry/Segment Competition Landscape Premium
13.1 Market Share Analysis
13.1.1 Global Market Share – Key Companies
13.1.2 Market Share by Region – Key companies
13.1.3 Market Share by Countries – Key Companies
13.1.4 Best Practices for Companies
14. Humanized Mouse Model Market – Key Company List by Country Premium Premium
15. Humanized Mouse Model Market Company Analysis
15.1 Company 1
15.2 Company 2
15.3 Company 3
15.4 Company 4
15.5 Company 5
15.6 Company 6
15.7 Company 7
15.8 Company 8
15.9 Company 9
15.10 Company 10
"*Financials for private companies would be provided on a best efforts basis”.
LIST OF TABLES
1.Global HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)1.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Global Industry Research
1.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Global Industry Research
1.2.1 CD34 Market 2023-2030 ($M)
1.2.2 PBMC Market 2023-2030 ($M)
1.2.3 BLT Market 2023-2030 ($M)
2.Global HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
2.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Global Industry Research
2.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Global Industry Research
2.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Global Industry Research
3.Global HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 (Volume/Units)
3.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 (Volume/Units) - Global Industry Research
3.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 (Volume/Units) - Global Industry Research
3.2.1 CD34 Market 2023-2030 (Volume/Units)
3.2.2 PBMC Market 2023-2030 (Volume/Units)
3.2.3 BLT Market 2023-2030 (Volume/Units)
4.Global HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 (Volume/Units)
4.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 (Volume/Units) - Global Industry Research
4.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 (Volume/Units) - Global Industry Research
4.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 (Volume/Units) - Global Industry Research
5.North America HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)
5.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
5.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
5.2.1 CD34 Market 2023-2030 ($M)
5.2.2 PBMC Market 2023-2030 ($M)
5.2.3 BLT Market 2023-2030 ($M)
6.North America HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
6.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Regional Industry Research
6.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Regional Industry Research
6.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Regional Industry Research
7.South America HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)
7.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
7.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
7.2.1 CD34 Market 2023-2030 ($M)
7.2.2 PBMC Market 2023-2030 ($M)
7.2.3 BLT Market 2023-2030 ($M)
8.South America HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
8.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Regional Industry Research
8.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Regional Industry Research
8.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Regional Industry Research
9.Europe HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)
9.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
9.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
9.2.1 CD34 Market 2023-2030 ($M)
9.2.2 PBMC Market 2023-2030 ($M)
9.2.3 BLT Market 2023-2030 ($M)
10.Europe HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
10.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Regional Industry Research
10.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Regional Industry Research
10.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Regional Industry Research
11.APAC HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)
11.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
11.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
11.2.1 CD34 Market 2023-2030 ($M)
11.2.2 PBMC Market 2023-2030 ($M)
11.2.3 BLT Market 2023-2030 ($M)
12.APAC HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
12.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Regional Industry Research
12.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Regional Industry Research
12.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Regional Industry Research
13.MENA HUMANIZED MOUSE MODEL MARKET, BY TYPE Market 2023-2030 ($M)
13.1 GENETIC HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
13.2 CELL BASED HUMANIZED MOUSE MODEL Market 2023-2030 ($M) - Regional Industry Research
13.2.1 CD34 Market 2023-2030 ($M)
13.2.2 PBMC Market 2023-2030 ($M)
13.2.3 BLT Market 2023-2030 ($M)
14.MENA HUMANIZED MOUSE MODEL MARKET, BY END USER Market 2023-2030 ($M)
14.1 PHARMACEUTICAL BIOTECHNOLOGY COMPANIES Market 2023-2030 ($M) - Regional Industry Research
14.2 CONTRACT RESEARCH ORGANIZATIONS Market 2023-2030 ($M) - Regional Industry Research
14.3 ACADEMIC RESEARCH INSTITUTES Market 2023-2030 ($M) - Regional Industry Research
LIST OF FIGURES
1.US Humanized Mouse Model Market Revenue, 2023-2030 ($M)2.Canada Humanized Mouse Model Market Revenue, 2023-2030 ($M)
3.Mexico Humanized Mouse Model Market Revenue, 2023-2030 ($M)
4.Brazil Humanized Mouse Model Market Revenue, 2023-2030 ($M)
5.Argentina Humanized Mouse Model Market Revenue, 2023-2030 ($M)
6.Peru Humanized Mouse Model Market Revenue, 2023-2030 ($M)
7.Colombia Humanized Mouse Model Market Revenue, 2023-2030 ($M)
8.Chile Humanized Mouse Model Market Revenue, 2023-2030 ($M)
9.Rest of South America Humanized Mouse Model Market Revenue, 2023-2030 ($M)
10.UK Humanized Mouse Model Market Revenue, 2023-2030 ($M)
11.Germany Humanized Mouse Model Market Revenue, 2023-2030 ($M)
12.France Humanized Mouse Model Market Revenue, 2023-2030 ($M)
13.Italy Humanized Mouse Model Market Revenue, 2023-2030 ($M)
14.Spain Humanized Mouse Model Market Revenue, 2023-2030 ($M)
15.Rest of Europe Humanized Mouse Model Market Revenue, 2023-2030 ($M)
16.China Humanized Mouse Model Market Revenue, 2023-2030 ($M)
17.India Humanized Mouse Model Market Revenue, 2023-2030 ($M)
18.Japan Humanized Mouse Model Market Revenue, 2023-2030 ($M)
19.South Korea Humanized Mouse Model Market Revenue, 2023-2030 ($M)
20.South Africa Humanized Mouse Model Market Revenue, 2023-2030 ($M)
21.North America Humanized Mouse Model By Application
22.South America Humanized Mouse Model By Application
23.Europe Humanized Mouse Model By Application
24.APAC Humanized Mouse Model By Application
25.MENA Humanized Mouse Model By Application
26.THE JACKSON LABORATORY, Sales /Revenue, 2015-2018 ($Mn/$Bn)
27.TACONIC BIOSCIENCES INC., Sales /Revenue, 2015-2018 ($Mn/$Bn)
28.HARBOUR BIOMED, Sales /Revenue, 2015-2018 ($Mn/$Bn)
29.HUMURINE TECHNOLOGIES INC., Sales /Revenue, 2015-2018 ($Mn/$Bn)
30.VITALSTAR BIOTECHNOLOGY CO. LTD., Sales /Revenue, 2015-2018 ($Mn/$Bn)
31.CROWN BIOSCIENCE INC., Sales /Revenue, 2015-2018 ($Mn/$Bn)
32.INGENIOUS TARGETING LABORATORY, Sales /Revenue, 2015-2018 ($Mn/$Bn)
33.AXENIS S.A.S., Sales /Revenue, 2015-2018 ($Mn/$Bn)
34.TRANS GENIC, INC., Sales /Revenue, 2015-2018 ($Mn/$Bn)
35.GENOWAY S.A., Sales /Revenue, 2015-2018 ($Mn/$Bn)