Large & Small-Scale Bioprocessing Market - Forecast(2024 - 2030)

Report Code: HCR 18452 Report Format: PDF + Excel

Large and Small Scale Bioprocessing Market Overview

Large and Small Scale Bioprocessing Market size was estimated at $30.32 billion in 2020, projected to grow at a CAGR of 6.2% during the forecast period 2021-2026. Large and Small Scale Bioprocessing industry has witnessed huge demand over the last decade owing to biopharmaceuticals need. Bioprocess or fermentation is a major component of old and modern biotechnology methods and usually involve entire living cells, organelles, or enzymes as a biocatalyst, and aims to bring about some chemical or physical improvements of the biochemical material extracted from the medium. 

Ultrafiltration (UF) is an operation unit which separates large solutes from small solutes and solvents. Excipients are inert pharmaceutical ingredients used in the formulation of products. Excipients are important and play a vital role in the drug development process, as well as the formulation and administration of stable dosage forms. According to European Pharmaceutical Review, Epileptic patients in Australia in the late 1960s who were taking phenytoin capsules suffered extreme intoxication as a result of a poor excipient option. 

Thin porous rigid UF membranes are used in UF as flat sheets or tubes. These separate solutes by holding and moving them based on their size and, secondarily, by charge or other fields acting on the solute-surface interaction.

Report Coverage

The report: “Large and Small Scale Bioprocessing Market Forecast (2021-2026)”, by Industry ARC, covers an in-depth analysis of the following segments.
By Type: Small Scale, Industrial Scale
By Use: Single-Use, Multi-Use
By Product: Cell Culture Products, Fermenters /Bioreactors, Filtration Assemblies, Bioreactors Accessories, Bags & Containers
By Workflow: Fermentation, Upstream Processing, Down Stream processing
By Application: Biopharmaceuticals, Environmental Aids, Speciality Industrial Chemicals
By Mode: In-House, Outsourced
By Geography: North America (U.S., Canada, Mexico), Europe (Germany, U.K., France, Italy, Spain, Russia and Rest of Europe), Asia Pacific (China, Japan, India, South Korea, Australia & New Zealand, and Rest of Asia Pacific), South America (Brazil, Argentina and Rest of South America), and Rest of the World (Middle East and Africa)

Key Takeaways

  • Based on geography, North America Large and Small Scale Bioprocessing Market held the largest revenue share of 38% in 2020 attributed to the high disposable income in the region and rise in demand for biopharmaceuticals.
  • Significant upsurge in the R&D initiatives by the major players in various regions coupled with the government initiatives are driving the market.
  • In the coming years, biopharmaceuticals production is projected to be a lucrative source of revenue for the pharmaceutical industry. Nano-biocatalysts, for example, were developed to increase turnaround times by increasing enzyme activity and stability, thus increasing bioproduction.

Large and Small Scale Bioprocessing Market: Market Share (%) by Region, 2020

Large and Small Scale Bioprocessing Market

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Large and Small Scale Bioprocessing Market Segment Analysis – By Product

Based on Product, Large and Small Scale Bioprocessing Market is segmented into Fermenters /Bioreactors, Cell Culture Products, Bioreactors Accessories, Filtration Assemblies, Bags & Containers. Fermenters/Bioreactors segment held the majority of revenue market share in 2020 attributed to the high consumption rate and large-scale bioproduction requirements from major industry participants. Automated cell culturing with specialized bioreactor designs is critical for the production of value-added goods, aids the segment's growth. 

Large-scale fermentations are used to produce large amounts of ethanol, which is used in the manufacture of food, alcohol, and even gasoline. The availability of the diversified range of bioreactors on the basis of size, operation mode, fluid flow type, applications, and usage type are projected to propel revenue of the segment in the upcoming years. 

Cell culture products segment is poised to grow with the fastest CAGR of 6.6% in the forecast period 2021-2026 owing to ongoing advances in cell line growth, such as the development of recombinant cell lines. The production of biopharmaceutical-derived cell lines from mammalian cell lines is expected to boost this segment's development.

Large and Small Scale Bioprocessing Market Segment Analysis – By Type:

Based on Type, Large and Small Scale Bioprocessing market is segmented into Small Scale, Industrial Scale. Industrial Scale segment held the highest revenue market share in 2020. The growth in the market is mainly attributed to the market's constant implementation of techniques and tools to help industrial-scale bioprocessing increased the adoption of industrial-scale bioprocessing. For example, GE Healthcare launched Capto Q XP chromatography resin in June 2016. These chromatography resins are powerful anion exchangers that are used in the industrial purification of large-scale biomolecules. These measures are anticipated to positively impact the segment's growth in the forecast time-frame. 

Batch fermentations, fed-batch operations, and continuous cultures are all options for industrial fermentations. Continuous fermentations are uncommon, compared to batch and fed-batch operations. Excipients in pharmaceuticals are simply something that isn't the active pharmaceutical ingredient. Small Scale segment is expected to witness the fastest CAGR of 6.9% in the forecast period 2021-2026.  As part of upstream processing, small scale bioreactors provide parallel processing and enable the evaluation of a series of experiments for bioprocess optimization. This factor is projected to support small-scale bioprocessing's projected development.

Large and Small Scale Bioprocessing Market Segment Analysis – By Geography:

On the basis of Geography, North America Large and Small Scale Bioprocessing Market held 38% of revenue share in 2020. This is majorly attributed to the technological advancement and cutting-edge biomanufacturing R&D. Other important factors affecting the market's success in this area include developed infrastructure and growing funds for bioprocessing technology. Furthermore, the large share of this segment can be attributed to the existence of a large number of biomanufacturing facilities in this area. Asia-Pacific market is forecast to rise with the fastest CAGR for the period 2021-2026. Several companies in the area are outsourcing biologics manufacturing and clinical trials, and it is a key factor driving development in this sector. Other facilities are beginning to establish manufacturing strategies for GMP production for key markets, with capability involving commercial-scale stainless steel and single-use bioreactors, while new facility construction and expansions represent the demand for biologics for domestic consumption. 

Large and Small Scale Bioprocessing Market Segment Analysis-Drivers

Increasing Funding by the Governments:

The market is also expected to expand as funding and investments to support the production and study of new biopharmaceuticals expand. The Indian government, for example, initiated a National Biopharmaceutical Mission in 2017. The government has invested US $250 million in the initiative, which includes a US$ 125 million loan from the World Bank, to facilitate the production of biological drugs in India. The Johns Hopkins University School of Medicine (JHUSM) teamed up with the University of Liverpool in the year 2017 for creating novel nanomedicine methods for the HIV therapy. Also, they secured a grant of $3 million from the National Institutes of Health (NIH) for development of enduring R&D and new technologies.

Large and Small Scale Bioprocessing Market Segment Analysis-Challenges

Single Use Bioreactors/Fermenters:

Single-use bioreactors are often made of plastic derivatives. In addition to concerns about possible leachable and extractable materials, routine large-scale disposal of such plastic reactors is also a concern for the environment. Furthermore, the reactor bag's insulating plastic material prevents efficient heat transfer, reducing the thermal jacket's impact. Film-related threats, unit management risks, operation risks, and supply chain risks are all major risks associated with single-use technology. As a result, it's difficult for biopharmaceutical companies to trust the integration of single-use technologies into bioprocessing process steps and applications. The industry had seen evidence that a single bag failure could cost a company between $100,000 and $1 million, and that leaks in single-use systems could cost a company up to $20 million per year.

Large and Small Scale Bioprocessing Market Segment Landscape:

Product launches, mergers and acquisitions, joint ventures and geographical expansions are key strategies adopted by players in the Large and Small Scale Bioprocessing Market. Large and Small Scale Bioprocessing Market top 10 companies are Thermo Fisher Scientific Inc., Applikon Biotechnology, Merck KGaA, Samsung Biologics, Eppendorf AG, Lonza, PBS Biotech Inc, Binex Co. Ltd, Finesse, CellGenix GmbH Meissner Filtration Products Inc.,

Developments:

  • In June 2019, MabPlex has announced opening of its subsidiary in Zhangjiang (Hub of Dozens of biotech companies), Shangai in order to serve process development outsourcing needs.
  • In May 2019, WuXi Biologics has announced to construct a new 1.3million sq. ft manufacturing facility center for the innovative biologics in Chengdu.

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Report Code: HCR 18452

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1. Large and Small Scale Bioprocessing Market - Overview
    1.1 Definitions and Scope
2. Large and Small Scale Bioprocessing Market - Executive Summary
    2.1 Market Revenue and Key Trends by Company
    2.2 Key trends by Type
    2.3 Key trends by Use
    2.4 Key trends by Product
    2.5 Key trends by Workflow
    2.6 Key trends by Application
    2.7 Key trends by Mode
    2.8 Key trends by Geography
3. Large and Small Scale Bioprocessing Market – Comparative Analysis
    3.1 Product Benchmarking – Key Companies
    3.2 Financial Analysis – Key Companies
    3.3 Market Value Split - Key Companies
    3.4 Patent Analysis – Key Companies
    3.5 Pricing Analysis – Average Selling Price
4. Large and Small Scale Bioprocessing Market - Startup Companies Scenario Premium
    4.1 Key Startup Company Analysis by
        4.1.1 Investment
        4.1.2 Revenue
        4.1.3 Venture Capital and Funding Scenario
5. Large and Small Scale Bioprocessing Market – Industry Market Entry Scenario Premium Premium
    5.1 Regulatory Framework Overview
    5.2 New Business and Ease of Doing business index
    5.3 Case Studies of Successful Ventures
6. Large and Small Scale Bioprocessing Market Forces
    6.1 Market Drivers
    6.2 Market Constraints/Challenges
    6.3 Porters five force model
        6.3.1 Bargaining power of suppliers
        6.3.2 Bargaining powers of customers
        6.3.3 Threat of new entrants
        6.3.4 Rivalry among existing players
        6.3.5 Threat of substitutes
7. Large and Small Scale Bioprocessing Market – Strategic Analysis
    7.1 Value Chain Analysis
    7.2 Opportunities Analysis
    7.3 Market Life Cycle
8. Large and Small Scale Bioprocessing Market – By Type (Market Size –$Million/$Billion)
    8.1 Small Scale
    8.2 Industrial Scale
9. Large and Small Scale Bioprocessing Market – By Use (Market Size –$Million/$Billion)
    9.1 Single Use
    9.2 Multiple Use
10. Large and Small Scale Bioprocessing Market – By Product (Market Size –$Million/$Billion)
    10.1 Cell Culture Products
    10.2 Fermenters/Bioreactors
    10.3 Filtration Assemblies
    10.4 Bioreactors Accessories
    10.5 Bags & Containers
11. Large and Small Scale Bioprocessing Market – By Workflow (Market Size –$Million/$Billion)
    11.1 Fermentation
    11.2 Upstream Processing
    11.3 Downstream Processing
12. Large and Small Scale Bioprocessing Market – By Application (Market Size –$Million/$Billion)
    12.1 Biopharmaceuticals
    12.2 Environmental Aids
    12.3 Specialty Industrial Chemicals
13. Large and Small Scale Bioprocessing Market – By Mode (Market Size –$Million/$Billion)
    13.1 In-House
    13.2 Outsourced
14. Large and Small Scale Bioprocessing Market - By Geography(Market Size –$Million/$Billion)
    14.1 North America
        14.1.1 U.S.
        14.1.2 Mexico
        14.1.3 Canada
    14.2 Europe
        14.2.1 U.K.
        14.2.2 France
        14.2.3 Germany
        14.2.4 Italy
        14.2.5 Spain
        14.2.6 Russia
        14.2.7 Rest of Europe
    14.3 Asia Pacific
        14.3.1 China
        14.3.2 India
        14.3.3 Japan
        14.3.4 South Korea
        14.3.5 Australia & New Zealand
        14.3.6 Rest of APAC
    14.4 South America
        14.4.1 Brazil
        14.4.2 Argentina
        14.4.3 Rest of South America
    14.5 Rest of the World
        14.5.1 Middle East
        14.5.2 Africa
15. Large and Small Scale Bioprocessing Market - Entropy
16. Large and Small Scale Bioprocessing Market – Industry/Segment Competition Landscape Premium
    16.1 Market Share Analysis
        16.1.1 Global Market Share – Key Companies
        16.1.2 Market Share by Region – Key companies
        16.1.3 Market Share by Countries – Key Companies
        16.1.4 Best Practices for Companies
17. Large and Small Scale Bioprocessing Market – Key Company List by Country Premium Premium
18. Large and Small Scale Bioprocessing Market Company Analysis
    18.1 Company 1
    18.2 Company 2
    18.3 Company 3
    18.4 Company 4
    18.5 Company 5
    18.6 Company 6
    18.7 Company 7
    18.8 Company 8
    18.9 Company 9
    18.10  Company 10
"*Financials for private companies would be provided on a best efforts basis”.

LIST OF TABLES

1.Global Competitive Landscape Market 2023-2030 ($M)
1.1 Market Participation Categorization Market 2023-2030 ($M) - Global Industry Research
2.Global Competitive Landscape Market 2023-2030 (Volume/Units)
2.1 Market Participation Categorization Market 2023-2030 (Volume/Units) - Global Industry Research
3.North America Competitive Landscape Market 2023-2030 ($M)
3.1 Market Participation Categorization Market 2023-2030 ($M) - Regional Industry Research
4.South America Competitive Landscape Market 2023-2030 ($M)
4.1 Market Participation Categorization Market 2023-2030 ($M) - Regional Industry Research
5.Europe Competitive Landscape Market 2023-2030 ($M)
5.1 Market Participation Categorization Market 2023-2030 ($M) - Regional Industry Research
6.APAC Competitive Landscape Market 2023-2030 ($M)
6.1 Market Participation Categorization Market 2023-2030 ($M) - Regional Industry Research
7.MENA Competitive Landscape Market 2023-2030 ($M)
7.1 Market Participation Categorization Market 2023-2030 ($M) - Regional Industry Research

LIST OF FIGURES

1.US Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
2.Canada Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
3.Mexico Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
4.Brazil Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
5.Argentina Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
6.Peru Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
7.Colombia Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
8.Chile Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
9.Rest of South America Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
10.UK Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
11.Germany Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
12.France Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
13.Italy Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
14.Spain Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
15.Rest of Europe Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
16.China Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
17.India Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
18.Japan Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
19.South Korea Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
20.South Africa Large & Small-Scale Bioprocessing Market Revenue, 2023-2030 ($M)
21.North America Large & Small-Scale Bioprocessing By Application
22.South America Large & Small-Scale Bioprocessing By Application
23.Europe Large & Small-Scale Bioprocessing By Application
24.APAC Large & Small-Scale Bioprocessing By Application
25.MENA Large & Small-Scale Bioprocessing By Application