Breast Cancer Liquid Biopsy Market - Forecast(2024 - 2030)

Breast Cancer Liquid Biopsy Market Overview

Breast Cancer Liquid Biopsy Market size is expected to be valued at $1.7 billion by the end of the year 2030 and the Breast Cancer Liquid Biopsy Market is set to grow at a CAGR of 21.8% during the forecast period from 2024-2030. The breast cancer liquid biopsy market is experiencing rapid growth, driven by the increasing prevalence of breast cancer, increasing preference of non-invasive procedures, advancements in technological capabilities and increasing breast cancer awareness programs. Liquid biopsy offers a non-invasive approach to cancer detection and monitoring, providing valuable insights into tumor biology through the analysis of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). This innovative technology enables earlier disease detection, real-time assessment of treatment efficacy, and the development of tailored treatment plans. While challenges such as standardization and assay sensitivity persist, the overall market trajectory is positive, with significant potential to improve patient outcomes.

The liquid biopsy market is at the forefront of medical innovation, heralding a new era of precision medicine. By analyzing circulating biomarkers in bodily fluids, primarily blood, liquid biopsy offers a non-invasive alternative to traditional tissue biopsies. Precision oncology, a specialized application of personalized medicine, is revolutionizing the breast cancer liquid biopsy market. By focusing on identifying unique molecular targets within tumors, precision oncology has spurred a significant demand for biopsies capable of accurately capturing and analyzing these critical biomarkers. Also, the surge in funding for minimally invasive cancer diagnostics is largely attributed to the rapid advancements in liquid biopsy technology. investors are recognizing the immense potential of liquid biopsy and pouring significant resources into research and development to bring these technologies to market. MiRXES secured $50 million in Series D funding in July 2023 to develop liquid biopsy products for colorectal cancer and early cancer detection. Concurrently, Epic Sciences raised $24 million in Series G funding in April 2023 to focus on liquid biopsy solutions for metastatic breast cancer. These funding rounds underscore the growing interest and investment in liquid biopsy as a promising diagnostic tool.

Report Coverage

The report: “Breast Cancer Liquid Biopsy Market – Forecast (2024-2030)”, by IndustryARC, covers an in-depth analysis of the following segments of the Breast Cancer Liquid Biopsy MarketIndustry.

By Circulating Biomarkers- Circulating Tumor Cells (CTCs) , Cell-free DNA (cfDNA), Cell- Free RNA (cfRNA), Circulating Tumor DNA (ctDNA), Circulating Tumor RNA (ctRNA), Extracellular Vesicles (EVs) and Other Biomarkers

By Product- Consumables, Instruments and Services.

By Application- Early Detection, Therapy Selection, Treatment Monitoring and Recurrence Monitoring

By End User- Research Institutes, Public Health Laboratories , Hospitals, Molecular Laboratories, Pathology Laboratories and Others.

By Geography: North America (USA, Canada, Mexico), Europe (Germany, UK, France, Italy, France, Netherlands, Belgium Spain, Russia and Rest of Europe), APAC (China, Japan India, South Korea, Australia, New Zealand, Indonesia, Taiwan, Malaysia), South America (Brazil, Argentina, Colombia, Chile and Rest of South America) and RoW (Middle East and Africa).

Key Takeaways

• North America is expected to hold a significant share of the breast cancer liquid biopsy market, due to a robust healthcare infrastructure, early adoption of innovative technologies of Liquid Biopsy, substantial research investments, and favorable regulatory environments into health care landscape.
• Kits and reagents are the primary revenue contributors in the breast cancer liquid biopsy market due to their consumable nature and their demand for every test performed.
• Increase in regulatory approvals for liquid biopsy tests is expected to have a positive effect on the market by fostering investor confidence on reliability and encouraging wider adoption by emerging markets.
•  Prominent manufacturers contribute to strengthening healthcare systems improving patient outcomes, and driving economic growth in expanding healthcare infrastructure and penetrating emerging markets.

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Breast Cancer Liquid Biopsy Market- By Circulating Biomarker

Circulating Tumor DNA (ctDNA) is currently the dominant type of biomarker in the liquid biopsy market. ctDNA can be detected in very small quantities, allowing for early cancer detection and can provide information about various aspects of the tumor, including mutations, copy number variations, and methylation patterns. It has gained significant traction due to its sensitivity, versatility, and the advancements in sequencing technologies have significantly improved the ability to detect and analyze ctDNA. In March 2023, Reveal Genomics, S.L., a Barcelona-based biotechnology start-up seeking to revolutionize precision oncology through biomarker innovation, announced a new addition to its pipeline consisting of a novel biomarker approach in liquid biopsy for patients with advanced cancer. Reveal Genomics machine learning-based technology applied to ctDNA was able to predict drug response and survival outcome in patients with metastatic breast cancer treated with endocrine therapy and CDK4/6 inhibitors.

Breast Cancer Liquid Biopsy Market- By End-User

Reference laboratories ie specifically the pathology services, are currently the predominant players in the breast cancer liquid biopsy market. These Laboratories are referred as the Backbone of Breast Cancer Liquid Biopsy. These laboratories offer a comprehensive range of tests, including histopathology, cytology, immunohistochemistry, molecular pathology, and flow cytometry, to support accurate diagnosis, treatment planning, and disease monitoring. Their expertise in handling complex samples and utilizing advanced technologies is instrumental in improving patient outcomes. While hospitals and physician offices are progressively incorporating liquid biopsy into their diagnostic offerings, reference laboratories continue to hold a substantial market share due to their comprehensive expertise and capacity for complex testing. In June 2023, X-ZELL formed a partnership with Germany-based MVZ for pathology to utilize cryoimmunostaining technology in the treatment of early-stage prostate cancer. 

Breast Cancer Liquid Biopsy Market- By Geography

In North America, particularly the United States, the high prevalence of cancer, including breast cancer, is met with substantial healthcare investment. The U.S. has one of the highest healthcare spending rates per capita globally, which supports the adoption of innovative diagnostic tools like liquid biopsies. This spending includes funding for research, development, and the implementation of advanced technologies in clinical settings. In 2023, healthcare expenditure in North America was substantial, with the United States and Canada investing heavily in their healthcare systems. According to the Centers for Medicare & Medicaid Services (CMS), the U.S. spent approximately $4.3 trillion on healthcare, representing about 18.3% of the country's GDP and anticipates reaching approximately $4.5 trillion in 2024. This high level of spending underscores the nation's commitment to advanced medical technologies and comprehensive care that supports a robust healthcare system, facilitating access to advanced diagnostic tools and treatments. Similarly, the Canadian Institute for Health Information (CIHI) reported that Canada’s healthcare expenditure was roughly 11.5% of its GDP in 2023 and forecasts an increase of 3.5% in Canada’s healthcare expenditure, which is expected to reach approximately US$230 billion. This rise reflects continued investments in healthcare services and innovations, supporting advancements in diagnostic and treatment technologies.The region's supportive regulatory environment, exemplified by the FDA’s efficient approval processes, further facilitates the rapid market introduction of new technologies. Combined with a competitive market presence, favorable funding, and reimbursement policies, North America is well-positioned to sustain its leadership in the breast cancer liquid biopsy market.

Key Drivers

Rising Prevalence of Breast Cancer

The escalating incidence of breast cancer is a primary driver for the growth of the liquid biopsy market. According to the World Health Organization (WHO), breast cancer is the most frequent type of cancer among women across the globe. Approximately 2.1 million women suffer from breast cancer every year, and it leads to the highest number of cancer-related deaths among women. As the number of new breast cancer cases continues to rise, there is a corresponding increase in demand for early detection, monitoring, and treatment options increases, driving the adoption of liquid biopsy as a valuable tool. The rising prevalence of chronic diseases, including obesity, diabetes, and metabolic disorders, is directly linked to the increasing incidence of breast cancer. This interconnected health crisis presents a significant opportunity for the liquid biopsy market. Liquid biopsy, with its non-invasive nature and potential for early detection, has emerged as a promising tool to address the challenges posed by breast cancer and can play a pivotal role in improving overall patient outcomes and addressing the growing burden of these conditions.

Adoption of non-invasive diagnostic techniques

The adoption of non-invasive diagnostic techniques, particularly liquid biopsy, is rapidly gaining traction in the breast cancer landscape. Traditional methods like mammograms and tissue biopsies, while effective, often involve invasive procedures that can cause discomfort and anxiety. Liquid biopsy offers a less invasive alternative by analyzing circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), in blood samples. This approach enables earlier detection, real-time monitoring of disease progression, and personalized treatment plans. This approach offers a significant advantage over traditional invasive methods by providing a dynamic view of tumor progression without subjecting patients to the risks and discomfort associated with tissue biopsies. While challenges such as standardization and sensitivity remain, ongoing research and technological advancements are steadily improving the clinical utility of liquid biopsy in breast cancer management. In May 2023, aiGENE secured funding from the Colorado Office of Economic Development and International Trade (OEDIT) to develop a liquid biopsy product capable of detecting multiple types of cancer at an early stage and monitoring disease progression.

Key Challenges

Standardization and reproducibility

While the technology has shown great promise, there is a lack of standardized protocols for sample collection, processing, and analysis. Despite advancements in technology, isolating and analyzing these biomarkers from a complex biological background can be difficult. Factors such as low tumor burden, the presence of background cfDNA, and the heterogeneity of CTCs contribute to this challenge. False-negative results can lead to misdiagnosis or delayed treatment, while false-positive results can cause unnecessary anxiety and invasive procedures. This variability between laboratories can lead to inconsistent results and hinder the adoption of liquid biopsy as a routine diagnostic tool. Overcoming this challenge requires collaborative efforts to develop standardized operating procedures and quality control measures to ensure reliable and comparable results across different testing centers.

Breast Cancer Liquid Biopsy- Key Market Players

Product/Service launches, approvals, patents and events, acquisitions, partnerships and collaborations are key strategies adopted by players in Breast Cancer Liquid Biopsy Market. The top 11 players in Breast Cancer Liquid Biopsy market are –

1. Qiagen
2. Thermo Fisher Scientific
3. Bio-Rad Laboratories Inc.
4. Guardant Health Inc
5. NeoGenomics Laboratories
6. F. Hoffmann-La Roche Ltd
7.  Myriad Genetics, Inc
8. Angle PLC
9. Sysmex Corporation
10. Illumina Inc.
     

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